![]() Cytogenetic analysis: This involves a study of chromosomal abnormalities.The next step involves examining the marrow under a microscope to check for abnormalities and cellular changes. The doctor inserts a needle into the hip bone to remove a marrow sample. Bone marrow biopsy: This test involves removing bone marrow, most often from a person’s hip bone.Peripheral blood smear: Doctors can use a blood smear to check the size and shape of blood cells, the specific patterns of WBCs, and the percentage of immature WBCs.Complete blood count: This test measures the number of WBCs, platelets, and RBCs in the blood, as well as the hemoglobin level.Other possible diagnostic tests for CML include: A high WBC count is not usually enough to confirm a diagnosis. In addition to checking the WBC count, doctors will likely order additional tests to confirm a suspected diagnosis. As these cells do not function normally, the raised count can lead to the development of certain CML symptoms, such as: This increase in immature cells raises the WBC count. It results in the bone marrow producing excess myeloblasts that do not function correctly. This gene change is responsible for the growing and rapid dividing of CML cells. In this case, the ABL1 gene from chromosome 9 joins to the BCR gene on chromosome 22, forming the BCR-ABL1 fusion gene, which some people also refer to as the Philadelphia chromosome. This means that the chromosomes swap part of their code. In most cases, a translocation occurs between chromosomes 9 and 22. Bone marrow is the spongy tissue inside some bones that produces WBCs.ĬML typically results from changes within the DNA of cells. Although they only account for about 1% of a person’s blood, they play an essential role in protecting the body from infections. WBCs, also known as leukocytes, are an important component of blood.
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